2-Phenoxyaniline Chemical Properties

Melting point:

47-49 °C(lit.)

Boiling point:

170 °C18 mm Hg(lit.)

Density 

1.0936 (rough estimate)

refractive index 

1.5300 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Slightly soluble in chloroform and methanol.

form 

Crystalline Powder or Flakes

pka

3.78±0.10(Predicted)

color 

Brown to gray

BRN 

777766

Stability:

Hygroscopic

CAS DataBase Reference

2688-84-8(CAS DataBase Reference)

NIST Chemistry Reference

2-Aminodiphenyl ether(2688-84-8)

EPA Substance Registry System

o-Phenoxyaniline (2688-84-8)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

26-37/39-36/37/39-36

RIDADR 

2811

WGK Germany 

3

RTECS 

BY7940000

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29222990

Toxicity

LD50 ivn-mus: 212 mg/kg TXCYAC 8,347,77

MSDS

• Language:English Provider:2-Aminophenyl phenyl ether
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Phenoxyaniline Usage And Synthesis

Chemical Properties

Whitetolightyellowcrystalpowde

Uses

2-Phenoxyaniline serves as an antiinflammatory agent that inhibits preferentially COX-2 over COX-1. It is used in the preparation of sodium primary amide complex, 4-methyl-2-(2-phenoxyphenyl)azo-phenol and 2-acetoaminodiphenyl ether. Further, it is used to form complexes with beta-cyclodextrin.

Uses

2-Phenoxyaniline may be used in the preparation of sodium primary amide complex, 2-PhOC₆H₄NHNa·NMe[(CH₂)₂NMe₂]₂. It was used in the preparation of 2-acetoaminodiphenyl ether. It may be used in the preparation of 4-methyl-2-(2-phenoxyphenyl)azo-phenol.

General Description

2-Phenoxyaniline forms crystalline 2:1 (host-to-guest) inclusion complexes with β-cyclodextrin.

Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic vapors of NOx.

2-Phenoxyaniline(2688-84-8)Related Product Information

• C8E3
• 4,4'-Oxydiphthalic anhydride
• Triclosan
• 4,4'-Oxydianiline
• Phenylhydrazine
• PHENYL VALERATE
• Dimethyl ether
• Ethylbenzene
• Diphenyl ether
• 4-Nitro-2-phenoxyaniline
• NiMesulide EP IMpurity E
• N-(Methylsulfonyl)-4'-nitro-2'-phenoxyMethanesulfonanilide
• (2-PHENOXY)METHYLSULFONYLANILINE
• Diethyl ether
• 2-(p-tolyloxy)aniline
• 2-AMINO-4,4'-DICHLORODIPHENYL ETHER
• 5-Chloro-2-(2-chlorophenoxy)aniline
• Phenoxazine