1,4-Dihydroxynaphthalene Chemical Properties

Melting point:

191-192 °C (dec.)

Boiling point:

246.06°C (rough estimate)

Density 

1.0924 (rough estimate)

refractive index 

1.5178 (estimate)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

pK1:9.37;pK2:10.93 (26°C，μ=0.65)

color 

Grey

Water Solubility 

slightly soluble

BRN 

1307689

CAS DataBase Reference

571-60-8(CAS DataBase Reference)

NIST Chemistry Reference

1,4-Naphthalenediol(571-60-8)

EPA Substance Registry System

1,4-Naphthalenediol (571-60-8)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

22-37/38-41-43-36/37/38-25

Safety Statements 

26-39-45-36/37/39-28A-24

WGK Germany 

3

RTECS 

QJ4730000

F 

8-10-16-23

HS Code 

2921450090

MSDS

• Language:English Provider:1,4-Dihydroxynaphthalene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

1,4-Dihydroxynaphthalene Usage And Synthesis

Chemical Properties

brown to greyish powder. 1,4-Naphthalenediol [571-60-8], mp 195℃, is synthesized by reduction of 1,4- naphthoquinone with sodium dithionite, or by hydrolysis of 4-amino-1-naphthol with 20 % sulfuric acid. It undergoes oxidation to give 1,4-naphthoquinone; amination to give 4-amino-1-naphthol; and methylation (MeOH – HCl) to give 4-methoxy-1-naphthol.

Uses

1,4-Dihydroxynaphthalene is frequently used in organic synthesis as a reagent. In particular, it is used in the synthesis of a pH independent and cell permeant fluorescent dye, a hydroxyl regioisomeric 3'',4''-benzorhodol, which can be used as a fluorescent chemosensor and biomarker for biological applications.

Definition

ChEBI: Naphthalene-1,4-diol is a naphthalenediol and a naphthohydroquinone.

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