ChemicalBook > Product Catalog > API > Circulatory system drugs > Antihypertensive drugs > CILAZAPRIL
CILAZAPRIL
CILAZAPRIL Basic information
- Product Name:
- CILAZAPRIL
- Synonyms:
-
- Initiss
- Justor
- Vascase
- 9[[1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]OCTAHYDRO-10-OXO-6HPYRIDAZINO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLIC ACID
- CILAZAPRIL EPC(
- CILAZAPRIL EPC(CRM STANDARD)
- CILAZAPRIL IMPURITY A1,1-DIMETHYLETHYL(1S,9S)-9-[[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]-10-OXO-OCTAHYDRO-6H-PYRIDAZINO[1,2A][1,2]DIAZEPINE-1-CABOXYLATE EPC
- [1S-[1α，9α(R^<*>^)]]-9-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1，2-α][1，2]diazepine-1-carboxylic acid monohydrate
- CAS:
- 92077-78-6
- MF:
- C22H31N3O5.H2O
- MW:
- 435.51
- EINECS:
- 200-258-5
- Product Categories:
-
- Inhibitors
- Mol File:
- 92077-78-6.mol
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CILAZAPRIL Chemical Properties
- Melting point:
- 98° (dec)
- alpha
- D20 -62.51° (c = 1% in ethanol)
- storage temp.
- Store at -20°C
- solubility
- Slightly soluble in water, freely soluble in methanol and in methylene chloride.
- pka
- pKa1 3.3; pKa2 6.4(at 25℃)
- form
- Solid
- color
- White to off-white
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CILAZAPRIL Usage And Synthesis
Description
Cilazapril is a new ACE inhibitor useful in the management of mild to moderate hypertension. Orally administered cilazapril is a prodrug which is de-esterified to its active diacid metabolite cilazprilat. Compared with enalapril and captopril, cilazapril is more potent and longer lasting.
Chemical Properties
White or almost white, crystalline powder.
Originator
Hoffmann-LaRoche (Switzerland)
Uses
Antihypertensive.
Definition
ChEBI: Cilazapril monohydrate is a hydrate that is the monohydrate of cilazapril. It is used for the treatment of hypertension and heart failure. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It contains a cilazapril.
brand name
Inhibace (Hoffmann-LaRoche).
CILAZAPRIL Preparation Products And Raw materials
Raw materials
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