Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Nervous system drugs >  Cholinergic drugs >  GALANTHAMINONE

GALANTHAMINONE

Basic information Safety Supplier Related

GALANTHAMINONE Basic information

Product Name:
GALANTHAMINONE
Synonyms:
  • GALANTHAMINONE
  • Narwedine
  • (4aS
  • 8aS)-
  • (4aS,8aS)-4a,5,9,10,11,12-Hexahydro-3-Methoxy-11-Methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one
  • GalantaMine interMediate ((-)-Narwedine)
  • GalantaMinone (GalantaMine IMpurity A)
  • 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-one,4a,5,9,10,11,12-hexahydro-3-Methoxy-11-Methyl-, (4aS,8aS)-
CAS:
510-77-0
MF:
C17H19NO3
MW:
285.34
Product Categories:
  • raw materials
  • Various Metabolites and Impurities
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites
  • Pharmaceuticals
Mol File:
510-77-0.mol
More
Less

GALANTHAMINONE Chemical Properties

Melting point:
175-180°C (dec.)
Boiling point:
397.4±42.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO : 10 mg/mL (35.05 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Cryst.
pka
7.84±0.20(Predicted)
More
Less

GALANTHAMINONE Usage And Synthesis

Description

This alkaloid occurs in several families of the Amaryllidaceae and is obtained as colourless prisms when crystallized from Me2CO. It is dextrorotatory with [α]25D + 100° (c 0.2, CHC13). It forms a crystalline picrate, m.p. 123°C; a methiodide, m.p. 195-6°C and a semicarbazone, indicative of a keto group, m.p. 240-1 °c (dec.).

Chemical Properties

White to Off-White

Uses

A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor

Uses

Narwedine is the biogenetic precursor of galanthamine, has been studied as a respiratory stimulator. It increases the amplitude and decreases the frequency of cardiac contractions and would therefore be of value in reducing blood loss during surgery. It also inhibits the action of narcotics and hypnotics, and increases the analgesic effect of morphine as well as the pharmacological effects of caffeine, carbazole, arecoline, and nicotine.

Definition

ChEBI: Narwedine is a benzazepine.

target

AChR | IL Receptor

References

Boit, Dapke, Beitner., Chem. Ber., 90,2197 (1957)

GALANTHAMINONESupplier

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Email
sales@chemreagents.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
China Langchem Inc.
Tel
021-58956006 15800617331
Email
sales@langchem.com
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Email
shyysw007@163.com