2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemical Properties

Melting point:

71-74 °C (lit.)

Boiling point:

99-100 °C (1 mmHg)

Density 

1.7917 (rough estimate)

vapor pressure 

5.8Pa at 25℃

refractive index 

1.5870 (estimate)

Flash point:

99-100°C/1mm

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform, Methanol

form 

Crystalline Powder

pka

0.33±0.10(Predicted)

color 

White to almost white

Water Solubility 

insoluble

BRN 

148988

InChIKey

GPIQOFWTZXXOOV-UHFFFAOYSA-N

LogP

2.105 at 25℃

CAS DataBase Reference

3140-73-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37-36

RIDADR 

UN3077

WGK Germany 

3

HS Code 

29339900

MSDS

• Language:English Provider:2-Chloro-4,6-dimethoxy-1,3,5-triazine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Chloro-4,6-dimethoxy-1,3,5-triazine Usage And Synthesis

Chemical Properties

white to almost white crystalline powder

Uses

2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines.

Uses

2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:

• The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
• The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
• The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
• The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.

General Description

2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

Synthesis

A preparation method of 2-chloro-4,6-dimethoxy-1,3,5-triazine comprises the following steps: using cyanuric chloride and sodium methoxide solid as reaction raw materials and N, N-dimethylformamide as a reaction solvent, gradually heating to obtain a 2-chloro-4,6-dimethoxy-1,3,5-triazine crude product, and finally, recrystallizing with heptane for purification. The reaction temperature is controlled to prepare the product, and the yield is up to 91%.

2-Chloro-4,6-dimethoxy-1,3,5-triazine(3140-73-6)Related Product Information

• Epichlorohydrin
• Dimethyldimethoxysilane
• 4-Methoxybenzylchloride
• 3-Chloropropyltrimethoxysilane
• Acetoxyacetyl chloride
• 1,3,5-Triazine
• Difluorochloromethane
• Chloroacetic acid
• F26 CDMT, 2-Chloro-4,6-bis(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)-1,3,5-triazine
• 2-Chloro-4,6-dimethoxy-1,3,5-triazine
• 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (3140-73-6)
• 2-CHLORO-4-(2,4-DIFLUOROPHENOXY)-6-METHOXY-1,3,5-TRIAZINE
• BIS-RF8 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE
• 2-CHLORO-4-(2,4-DIMETHYLPHENOXY)-6-METHOXY-1,3,5-TRIAZINE
• BIS-RF6 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE
• 2-CHLORO-4-(4-CHLORO-3-METHYLPHENOXY)-6-METHOXY-1,3,5-TRIAZINE
• 2-CHLORO-4,6-DI(4-FLUOROPHENOXY)-1,3,5-TRIAZINE
• Dimethoxy