Basic information Safety Supplier Related

2-Chloro-4,6-dimethoxy-1,3,5-triazine

Basic information Safety Supplier Related

2-Chloro-4,6-dimethoxy-1,3,5-triazine Basic information

Product Name:
2-Chloro-4,6-dimethoxy-1,3,5-triazine
Synonyms:
  • CDMT
  • AKOS 89995
  • 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE
  • 2-CHLORO-4,6-DIMETHOXY-TRIAZINE
  • Chlorodimethoxytriazine
  • 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE, 9 7%
  • 2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (CDMT)
  • 2-Chloro-4,6-dimethoxy-1
CAS:
3140-73-6
MF:
C5H6ClN3O2
MW:
175.57
EINECS:
221-541-0
Product Categories:
  • Miscellaneous
  • Aromatics
  • Biochemistry
  • Coupling Reactions (Peptide Synthesis)
  • Heterocycles
  • Miscellaneous Reagents
  • Starting Raw Materials & Intermediates
  • Peptide Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Triazines
  • TriazinesBuilding Blocks
  • bc0001
Mol File:
3140-73-6.mol
More
Less

2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemical Properties

Melting point:
71-74 °C (lit.)
Boiling point:
99-100 °C (1 mmHg)
Density 
1.7917 (rough estimate)
vapor pressure 
5.8Pa at 25℃
refractive index 
1.5870 (estimate)
Flash point:
99-100°C/1mm
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform, Methanol
form 
Crystalline Powder
pka
0.33±0.10(Predicted)
color 
White to almost white
Water Solubility 
insoluble
BRN 
148988
InChIKey
GPIQOFWTZXXOOV-UHFFFAOYSA-N
LogP
2.105 at 25℃
CAS DataBase Reference
3140-73-6(CAS DataBase Reference)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37-36
RIDADR 
UN3077
WGK Germany 
3
HS Code 
29339900

MSDS

More
Less

2-Chloro-4,6-dimethoxy-1,3,5-triazine Usage And Synthesis

Chemical Properties

white to almost white crystalline powder

Uses

2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines.

Uses

2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies:

  • The specific labeling of streptavidin by the modular method for affinity labeling (MoAL).
  • The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine.
  • The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines.
  • The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.

General Description

2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

2-Chloro-4,6-dimethoxy-1,3,5-triazine Preparation Products And Raw materials

Raw materials

2-Chloro-4,6-dimethoxy-1,3,5-triazineSupplier

XIANJU DOEASTCHEM Co., Ltd. Gold
Tel
0576-87788985 13586230158
Email
504833149@qq.com
Jinan Daen Pharmaceutical Technology Co., Ltd Gold
Tel
0531-68657833 15553112864
Email
2098511197@qq.com
Wisdom Drugs Co., Ltd. Gold
Tel
18261161868
Email
527536256@qq.com
Shaanxi Dideu Medichem Co. Ltd Gold
Tel
029-61856359 18690052321
Email
1027@dideu.com
Chengdu Kelai Hyde Pharmaceutical Technology Co., Ltd Gold
Tel
18482172240
Email
609320203@qq.com