12-AMINODODECANOIC ACID Chemical Properties

Melting point:

185-187 °C (lit.)

Boiling point:

349.7±15.0 °C(Predicted)

Density 

0.957±0.06 g/cm3(Predicted)

vapor pressure 

0Pa at 25℃

Flash point:

280 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Aqueous Acid (Slightly), Aqueous Base (Slightly)

form 

Solid

pka

pK1: 4.648(+1) (25°C)

color 

White to Off-White

Water Solubility 

137mg/L at 20℃

BRN 

907502

LogP

-0.607 at 24.6℃

CAS DataBase Reference

693-57-2(CAS DataBase Reference)

EPA Substance Registry System

12-Aminolauric acid (693-57-2)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29224999

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

12-AMINODODECANOIC ACID Usage And Synthesis

Description

12-Aminododecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.

Chemical Properties

Light beige powder

Uses

12-Aminolauric Acid is an amino acid used as a reagent in organic synthesis of several compounds including phenylbutazone which is a new long-acting agent which displays improved pharmacokinectics based on human serum albumin as a drug carrier.

Definition

ChEBI: 12-aminododecanoic acid is an omega-amino fatty acid that is dodecanoic acid in which one of the terminal amino hydrogens has been replaced by an amino group. It has a role as a bacterial metabolite. It is an omega-amino fatty acid and a medium-chain fatty acid.

Flammability and Explosibility

Non flammable

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