N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 Chemical Properties

solubility 

Soluble in Water, DMSO, DMF, DCM

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 Usage And Synthesis

Description

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG linker containing a cyanine dye with excitation/emmission maximum 649/667 nm as well as an azide group, which enables Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media.

Uses

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5(2107273-56-1)Related Product Information

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