2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID Chemical Properties

Melting point:

141-146℃

Boiling point:

301.6±42.0 °C(Predicted)

Density 

1.489±0.06 g/cm3(Predicted)

Flash point:

>110°(230°F)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

Solid

pka

4.51±0.10(Predicted)

Appearance

White to light yellow Solid

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2916399090

2-AMINO-5-TRIFLUOROMETHYL-BENZOIC ACID Usage And Synthesis

Uses

2-amino-5-(trifluoromethyl)benzoic Acid is a benzoic acid derivative whose molecular structure contains substituents amino and trifluoromethyl at positions 2 and 5. The substance can be used to prepare small molecule inhibitors or anticancer drugs, and is widely used in fields such as chemical or pharmaceutical manufacturing.

Synthesis

Step 2 Synthesis of 2-amino-5-(trifluoromethyl)benzoic acid: 2-nitro-5-(trifluoromethyl)benzoic acid (1.2 g, 4.78 mmol) was suspended in ethanol (10 mL) and 10% Pd/C catalyst (120 mg) was added. The hydrogenation reaction was carried out at room temperature and atmospheric pressure for 1 hour. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated to afford 2-amino-5-(trifluoromethyl)benzoic acid (900 mg, 85.2% yield) as a pale white solid. The resulting product could be used in subsequent reactions without further purification.

References

[1] Patent: WO2016/23826, 2016, A1. Location in patent: Page/Page column 52; 53

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