BETA-D-GLUCOPYRANOSIDURONIC ACID
BETA-D-GLUCOPYRANOSIDURONIC ACID Basic information
- Product Name:
- BETA-D-GLUCOPYRANOSIDURONIC ACID
- Synonyms:
-
- BETA-D-GLUCOPYRANOSIDURONIC ACID
- WOGONOSIDE
- (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid
- B-D-GLUCOPYRANOSIDURONICACID
- 5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid
- wogonin 7-O-beta-D-glucuronide
- 8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl
- β-D-Glucopyranosiduronic acid,5-hydroxy-
- CAS:
- 51059-44-0
- MF:
- C22H20O11
- MW:
- 460.39
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Miscellaneous Natural Products
- Mol File:
- 51059-44-0.mol
BETA-D-GLUCOPYRANOSIDURONIC ACID Chemical Properties
- Melting point:
- 226-227℃
- Boiling point:
- 820.7±65.0 °C(Predicted)
- Density
- 1.629
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- 2.73±0.70(Predicted)
- color
- Pale Yellow
- InChIKey
- LNOHXHDWGCMVCO-NTKSAMNMSA-N
BETA-D-GLUCOPYRANOSIDURONIC ACID Usage And Synthesis
Chemical Properties
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Scutellaria baicalensis.
Uses
Wogonoside is a flavonoid present in extracts from plant Radic scutellariae and provides antioxidant activity.
Definition
ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of wogonin.
General Description
Natural product derived from plant source.
Biochem/physiol Actions
Wogonoside, a flavanoid, is known for its anti-inflammatory properties. Wogonoside may have therapeutic potential for use in diseases which involve the development of inflammation and angiogenesis through its inhibition of LPS-induced angiogenesis.
in vivo
Wogonoside (80 mg/kg, oral gavage, once every other day) inhibits tumor growth and metastasis in MDA-MB-231 orthotopic model[3].
Wogonoside (40 or 80 mg/kg, i.p., every three days) inhibits tumor growth and reduces Bcl-2/Bax ratio in A549 cell xenograft mice[4].
Wogonoside (80 mg/kg, i.P., every other day for 14 days) also inhibits tumor growth in U937 xenograft model[5].
| Animal Model: | MDA-MB-231 orthotopic model[3] |
| Dosage: | 80 mg/kg |
| Administration: | oral gavage, once every other day |
| Result: | Inhibited tumor growth (46%) and metastasis in brain, lung, liver and bone. Increased the expression of E-cadherin and reduced the expression of MMP-9, vimentin and Twist1 at ?orthotopic site. |
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BETA-D-GLUCOPYRANOSIDURONIC ACID(51059-44-0)Related Product Information
- Wogonin
- Kidney Bean Extract
- WEDELOLACTONE
- WILFORINE
- Worenine
- WILFORDINE
- HYPERICUM PERFORATUM OIL
- WILFORGINE
- Whitefreshskinoil
- WILFORLIDE A
- White peony essential oil
- Witch hazel extract
- 2-ISOBUTYL-4-HYDROXY-4-METHYLTETRAHYDROPYRAN
- WITHAFERIN A
- (E)-4-[1-ethyl-2-(4-hydroxyphenyl)but-1-enyl]phenyl-beta-D-glucopyranosiduronic acid
- Methyl 2,3,4-tris-O-(phenylmethyl)-beta-D-Glucopyranosiduronic acid
- P-NITROPHENYL BETA-D-GLUCOPYRANOSIDURONIC ACID,4-NITROPHENYL-BETA-D-GLUCOPYRANOSIDURONIC ACID
- 5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL BETA-D-GLUCOPYRANOSIDURONIC ACID