ROSAPROSTOL Chemical Properties

Boiling point:

442.1±18.0 °C(Predicted)

Density 

0.981±0.06 g/cm3(Predicted)

pka

4.78±0.10(Predicted)

ROSAPROSTOL Usage And Synthesis

Description

Rosaprostol is an antisecretory and cytoprotective prostaglandin analog useful in the treatment of gastric and duodenal ulcers. Considerably less potent than enprostil or misoprostol, it is reported to lack the typical gastrointestinal and cardiovascular side effects of PGE derivatives.

Chemical Properties

Oily substance. Rosaprostol Sodium: C18H33NaO3. White solid. Acute toxicity LD50 in mice and rats (mg/kg): Approximately 3000 oral dose; >5000 oral dose.

Originator

Inatituto Biochemico Italiano (Italy)

Uses

Rosaprostol is a compound with antiulcer activity, and its enantiomers can be synthesized from the corresponding building blocks via a specific synthetic route involving multistep reactions and stereoselective transformations.

brand name

ROSAL

References

[1] Synthesis of Enantiomerically Pure Stereomers of Rosaprostol DOI:10.1021/acs.joc.5b01749

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