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simfibrate

Basic information Safety Supplier Related

simfibrate Basic information

Product Name:
simfibrate
Synonyms:
  • simfibrate
  • 1,3-Propanediol bis[2-(4-chlorophenoxy)-2-methylpropionate]
  • Bis[2-(4-chlorophenoxy)-2-methylpropanoic acid] 1,3-propanediyl
  • Cholesolvin
  • CLY-503
  • Sinfibrate
  • Propane-1,3-diyl bis(2-(4-chlorophenoxy)-2-methylpropanoate)
  • Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 1,1'-(1,3-propanediyl) ester
CAS:
14929-11-4
MF:
C23H26Cl2O6
MW:
469.35
EINECS:
2389987
Mol File:
14929-11-4.mol
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simfibrate Chemical Properties

Melting point:
51-53°
Boiling point:
bp0.03 197-200°; bp0.15 220-230°
Density 
1.2623 (estimate)
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Safety Information

Toxicity
LD50 in mice, rats (g/kg): 3.3-3.5; 7.3-8.0 orally (Nakanishi, J. Pharm. Soc. Japan)
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simfibrate Usage And Synthesis

Originator

Cholesorbin,Takeda,Japan,1971

Definition

ChEBI: Simfibrate is an organic molecular entity.

Manufacturing Process

A mixture of 22 grams of α-(p-chlorophenoxy)isobutyric acid, 3.8 grams of 1,3-propanediol, 0.5 gram of p-toluenesulfonic acid and 150 ml of xylene was refluxed. When the theoretically calculated amount of water had been removed, the xylene solution was washed with dilute aqueous sodium bicarbonate and then the xylene was distilled off. The residue was distilled under reduced pressure to give 11 grams (47% yield) of 1,3-propanediol bis[α-(p-chlorophenoxy)isobutyrate] boiling at 197° to 200°C/0.03 mm Hg.

Therapeutic Function

Antihyperlipidemic

simfibrateSupplier

LGM Pharma
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1-(800)-881-8210
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inquiries@lgmpharma.com
Aikon International Limited
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025-58851090 13611564524
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lwan@aikonchem.com
Shaanxi Dideu Medichem Co. Ltd
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+86-029-89586680 +86-18192503167
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1026@dideu.com
TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
Shaanxi Dideu Newmaterial Co., Ltd.
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029-87576359 15353716720
Email
1039@dideu.com