Methyl 4-bromo-2,6-difluorobenzoate Chemical Properties

Melting point:

41-43℃

Boiling point:

276.1±40.0 °C(Predicted)

Density 

1.652±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to light brown Solid

InChI

InChI=1S/C8H5BrF2O2/c1-13-8(12)7-5(10)2-4(9)3-6(7)11/h2-3H,1H3

InChIKey

JBXJLZRTTCGLNR-UHFFFAOYSA-N

SMILES

C(OC)(=O)C1=C(F)C=C(Br)C=C1F

Safety Information

HazardClass 

IRRITANT

HS Code 

2916399090

Methyl 4-bromo-2,6-difluorobenzoate Usage And Synthesis

Chemical Properties

Off-white powder

Uses

Methyl 4-bromo-2,6-difluorobenzoate is a pharmaceutical intermediate compound used in the preparation of contraceptive compositions.

Synthesis

(a) Synthesis of methyl 4-bromo-2,6-difluorobenzoate. At room temperature, (trimethylmethylsilyl) diazomethane (2.0 M ether solution, 15.0 mL, 30.0 mmol) was slowly added dropwise through a charging funnel to a mixture of dichloromethane (32.0 mL) and methanol (8.0 mL) of 4-bromo-2,6-difluorobenzoic acid (5.0 g, 21.10 mmol). The reaction mixture was stirred for 15 min and then concentrated under reduced pressure to afford methyl 4-bromo-2,6-difluorobenzoate (5.30 g, 21.11 mmol, 100% yield) as a clarified light orange oil. The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 7.17 (dd, J = 8.8, 1.5 Hz, 2H), 3.95 (s, 3H). Mass spectrometry (ES+) analysis showed m/e 251/253 [M + H]+.

References

[1] Patent: US2010/305133, 2010, A1. Location in patent: Page/Page column 34
[2] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 211; 212

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