4-Chloro-1-butanol Chemical Properties

Boiling point:

84-85 °C/16 mmHg (lit.)

Density 

1.088 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.453(lit.)

Flash point:

97 °F

storage temp. 

2-8°C

solubility 

Soluble in methanol, chloroform, and dimethyl sufoxide.

form 

Liquid

pka

15.01±0.10(Predicted)

color 

Clear colorless to light yellow

BRN 

1731408

InChIKey

HXHGULXINZUGJX-UHFFFAOYSA-N

CAS DataBase Reference

928-51-8(CAS DataBase Reference)

NIST Chemistry Reference

4-Chloro-1-butanol(928-51-8)

EPA Substance Registry System

1-Butanol, 4-chloro- (928-51-8)

Safety Information

Hazard Codes 

Xn,C,F

Risk Statements 

10-22-36/37/38-20/21/22-34-40

Safety Statements 

23-24/25-36/37/39-26-16-36/37

RIDADR 

UN 2920 8/PG 2

WGK Germany 

3

RTECS 

EL1325000

Hazard Note 

Harmful

TSCA 

Yes

HazardClass 

3.2

PackingGroup 

III

HS Code 

29055910

MSDS

• Language:English Provider:4-Chloro-1-butanol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Chloro-1-butanol Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Tetramethylene chlorohydrin is used inorganic synthesis.

Uses

4-Chloro-1-butanol is employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Uses

4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Definition

ChEBI: A primary alcohol that is butan-1-ol substituted by a chloro group at position 4.

General Description

4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.

Health Hazard

The toxicity of this compound is low. How ever, the acute toxic symptoms are those ofethylene and propylene chlorohydrins. Oralintake of this compound caused muscle con traction, gastrointestinal pain, ulceration, andliver injury in test animals.
LD50 value, oral (mice): 990 mg/kg
Tetramethylene chlorohydrin caused tumorsin lungs in test animals. Its carcinogenicity,however, is not yet fully established.

Fire Hazard

Flammable; flash point 36°C (97°F); vapor density 3.7 (air = 1); the vapor forms an explosive mixture with air, range is not reported. Fire-extinguishing agent: “alcohol” foam; a water spray may be used to cool fire-exposed containers and to flush any spill. It decomposes to HCl and tetrahydrofuran on heating.

Safety Profile

Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES and ALCOHOLS.

Waste Disposal

Tetramethylene chlorohydrin is burned ina chemical incinerator equipped with anafterburner and scrubber.

4-Chloro-1-butanol(928-51-8)Related Product Information

• Sodium tert-butoxide
• 1-Butanol
• tert-Butanol
• 2-Methyl-1-propanol
• Potassium tert-butoxide
• 3-Chloro-1,2-propanediol
• Ethambutol
• CYCLOBUTANE
• Epichlorohydrin
• TIROFIBAN HYDROCHLORIDE MONOHYDRATE
• 4-(4-Piperidyl)-1-butanol
• Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane)
• 1-Butanesulfonyl chloride
• 2-butyl-4-methylpyridine
• L-N-BUTYLSULFONYL-P-HYDROXYPHENYLALANINE
• 1-Methylethyl 1-butanesulfonate
• 4,4'-Dimethyl-2,2'-bipyridyl
• 1-Butanesulfonic acid methyl ester