2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE Chemical Properties

Melting point:

88-90 °C(Solv: ethanol (64-17-5))

Boiling point:

517.4±60.0 °C(Predicted)

Density 

1.419±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

1.27±0.29(Predicted)

Safety Information

HS Code 

2933599590

2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 5-bromo-2,4-bis(phenylmethoxy)-pyrimidine from 5-bromo-2,4-dichloropyrimidine and benzyl alcohol: 6.7 mL (65 mmol) of benzyl alcohol was dissolved in 70 mL of anhydrous toluene, and reacted with 2.9 g of NaH (60 mmol) under nitrogen protection until the gas production stopped. The resulting suspension was cooled to room temperature and slowly added dropwise to a solution of 5-bromo-2,4-dichloropyrimidine 4.5 g (20 mmol) with stirring, ensuring that the reaction temperature did not exceed 25 °C. The reaction was carried out at room temperature. After completion of the dropwise addition, the reaction was continued with stirring at room temperature for 12 hours. At the end of the reaction, the precipitated sodium chloride was removed by filtration and the solvent was evaporated to give 5-bromo-2,4-bis(phenylmethoxy)-pyrimidine 3.44 g in 93% yield.

References

[1] Patent: CN105237483, 2016, A. Location in patent: Paragraph 0039; 0040; 0041; 0042; 0043; 0053
[2] Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1612 - 1619
[3] Journal of Organic Chemistry, 1985, vol. 50, # 6, p. 841 - 847
[4] Inorganica Chimica Acta, 2012, vol. 380, # 1, p. 252 - 260

2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE(41244-53-5)Related Product Information

• 2,4-BIS(BENZYLOXY)PYRIMIDINE
• 2,4-DIETHOXYPYRIMIDINE
• 2 , 4-BIS(BENZYLOXY)-5-BROMOPYRIMIDINE
• 5-BROMO-2-ETHOXY-PYRIMIDINE
• 5-BROMO-2-HYDROXYPYRIMIDINE
• 5-bromo-1H-pyrimidin-4-one
• 5-Bromo-2-methoxypyrimidine
• 2-BENZYLOXY-5-BROMO-PYRIMIDINE
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