2-AMINO-4-FLUOROBENZOTHIAZOLE Chemical Properties

Boiling point:

101 °C

Density 

1.491±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

2.47±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

Safety Statements 

24/25

HS Code 

29342000

2-AMINO-4-FLUOROBENZOTHIAZOLE Usage And Synthesis

Chemical Properties

White solid

Synthesis

General procedure for the synthesis of 2-amino-4-fluorobenzothiazole from 1-(2-fluorophenyl)-2-thiourea: A solution of bromine (0.51 mL, 10.0 mmol) was added slowly and dropwise to a suspension of 1-(2-fluorophenyl)-2-thiourea (1.7 g, 10.0 mmol) in chloroform (25 mL) at room temperature. The reaction mixture was heated to reflux for 3 hours. Upon completion of the reaction, the solvent was removed by evaporation and water was added to the residue and neutralized with ammonium hydroxide solution. The resulting white precipitate was collected by filtration and dried to give 1.2 g (72% yield) of 2-amino-4-fluorobenzothiazole, which could be used in subsequent reactions without further purification.

References

[1] Patent: WO2004/11460, 2004, A2. Location in patent: Page 57
[2] Synthetic Communications, 1987, vol. 17, # 2, p. 229 - 240
[3] Journal of the Chemical Society [Section] C: Organic, 1969, p. 268 - 272

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