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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide

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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Basic information

Product Name:
6-(Bromomethyl)-2,4-pteridinediamine hydrobromide
Synonyms:
  • 2,4-pteridinediaMine, 6-(broMoMethyl)-, hydrobroMide
  • 2, 4-diaMino-6-(broMoMethyl)-pteridine HCL
  • 2,4-diamino-6-(bromomethyl)pteridine(for methotrexate)
  • 6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR
  • 2,4-Diamino-6-(bromomethyl)pteridine Hydrobromide
  • 6-(Bromomethyl)-2,4-diaminopteridine Hydrobromide
  • 2,4-PteridinediaMine, 6-(broMoMethyl)-, MonohydrobroMide
  • 6-(BroMoMethyl)-2,4-pteridinediaMine HydrobroMide (Technical Grade)
CAS:
52853-40-4
MF:
C7H8Br2N6
MW:
335.99
EINECS:
692-499-2
Product Categories:
  • Aromatics
  • Bases & Related Reagents
  • Aromatics Compounds
  • Inhibitors
  • Nucleotides
Mol File:
52853-40-4.mol
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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Chemical Properties

Melting point:
>195°C (dec.)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Light Brown to Brown
InChI
InChI=1S/C7H7BrN6.BrH/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6;/h2H,1H2,(H4,9,10,11,13,14);1H
InChIKey
KMQIBGKVZDBGAH-UHFFFAOYSA-N
SMILES
NC1=NC(N)=NC2=NC=C(CBr)N=C12.Br
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6-(Bromomethyl)-2,4-pteridinediamine hydrobromide Usage And Synthesis

Description

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide is a potent inhibitor of the enzyme nitroaldolase (EC 1.2.1.22) and has been shown to inhibit cell growth in murine leukemia cells. This reaction is mediated by the addition of bromide to isobutyl esters, leading to a benzyl ester intermediate which undergoes an electrophilic attack on nitroaldolase. The mechanism of action for this drug involves the inhibition of membrane transport and chloride ion influx, which are necessary for the proliferation of tumor cells. 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide also inhibits DNA synthesis through its effects on thymidylate synthase, preventing nucleotide production from thymine and dihydrofolate reductase activity.

Chemical Properties

Light Brown Solid

Uses

6-(Bromomethyl)-2,4-pteridinediamine hydrobromide can be used as organic synthesis intermediate and pharmaceutical intermediate.

Application

6-(Bromomethyl)-2,4-pteridinediamine Hydrobromide (Technical Grade) is a useful research chemical used in the preparation of novel methotrexate derivatives as antirheumatic agents as well as the preparation of pteridine reductase inhibitors.

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