6-BROMO-2,4-DICHLOROQUINAZOLINE Chemical Properties

Boiling point:

330.2±24.0 °C(Predicted)

Density 

1.851±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

pka

-1.19±0.30(Predicted)

form 

Solid

color 

Off-white

Water Solubility 

Slightly soluble in water.

InChI

InChI=1S/C8H3BrCl2N2/c9-4-1-2-6-5(3-4)7(10)13-8(11)12-6/h1-3H

InChIKey

LBAYOWRVZAKPLS-UHFFFAOYSA-N

SMILES

N1=C2C(C=C(Br)C=C2)=C(Cl)N=C1Cl

Safety Information

HS Code 

2933599590

6-BROMO-2,4-DICHLOROQUINAZOLINE Usage And Synthesis

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

The synthesis of 6-BROMO-2,4-DICHLOROQUINAZOLINE is as follows:BTC (0.65 g, 2.2 mmol in 6mL of PhCl) was added to astirred solution of tris(4-methoxyphenyl)phosphine oxide 3d(0.33 g, 0.9 mmol in 5mL PhCl) dropwise in a round botttomflask placed on an ice bath. After complete addition,the mixture was stirred for 30 min at room temperature.Then isatin-3-oximes (3 mmol) were added, and the mixturewas heated to 120 C until completion of the reaction(followed by TLC, n-hexane/ethyl acetate 10:1). Aftercooling, the mixture was then poured into 50mL ice waterand extracted with ethyl acetate (320 mL). The organiclayer was dried over anhydrous Na₂SO₄ and concentrated invacuo. The crude product was purified over column chromatography(n-hexane/ethyl acetate 10:1) to afford thepure produce 2,4-dichloroquinazolins. Tris(4-methoxyphenyl)phosphine oxide 3d was recovered by column chromatography(n-hexane/ethyl acetate 1:1).

6-BROMO-2,4-DICHLOROQUINAZOLINE(102393-82-8)Related Product Information

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