5,6,7,8-TETRAHYDRO-6-METHYL-1,6-NAPHTHYRIDIN-3-AMINE Chemical Properties

Boiling point:

324.1±42.0 °C(Predicted)

Density 

1.142±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

7.12±0.20(Predicted)

Appearance

White to yellow Solid

5,6,7,8-TETRAHYDRO-6-METHYL-1,6-NAPHTHYRIDIN-3-AMINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-amino-5,6,7,8-tetrahydro-6-methyl-1,6-naphthyridine from 6-methyl-3-nitro-5,6,7,8-tetrahydro-6-methyl-1,6-naphthyridine: To a mixture of ethanol (35 mL) and 2-methyltetrahydrofuran (35 mL) of intermediate 128 (1.50 g, 7.76 mmol) was added palladium/carbon catalyst ( 10 wt.%) (826.24 mg, 0.77 mmol) and the reaction mixture was stirred under hydrogen atmosphere for 2 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed with ethanol. The filtrate was concentrated under reduced pressure to give 1.33 g of Intermediate 129, which crystallized on standing (quantitative yield, 95% purity based on 1H NMR analysis, yellow oily).

References

[1] Patent: WO2018/2219, 2018, A1. Location in patent: Page/Page column 290; 291
[2] Synthetic Communications, 2001, vol. 31, # 5, p. 787 - 797

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