NUTLIN-3
NUTLIN-3 Basic information
- Product Name:
- NUTLIN-3
- Synonyms:
-
- (+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE
- NUTLIN-3
- 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
- 4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
- Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
- 4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one
- Nutlin-3, >=98%
- NUTLIN-3 (Free base)
- CAS:
- 548472-68-0
- MF:
- C30H30Cl2N4O4
- MW:
- 581.49
- EINECS:
- 200-258-5
- Product Categories:
-
- Inhibitors
- Mol File:
- 548472-68-0.mol
NUTLIN-3 Chemical Properties
- Melting point:
- >132oC (dec.)
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 20 mg/mL, soluble
- pka
- 14.35±0.20(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
- InChIKey
- BDUHCSBCVGXTJM-UHFFFAOYSA-N
MSDS
- Language:English Provider:SigmaAldrich
NUTLIN-3 Usage And Synthesis
Description
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.
Uses
(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.
Definition
ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.
Biochem/physiol Actions
Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.
storage
Store at -20°C
References
1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859
NUTLIN-3Supplier
- Tel
- 021-2221346380 021-54220652 17701603001
- bankpharma@163.com
- Tel
- sales@boylechem.com
- Tel
- +86-21-20908456
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- Tel
- 0512-62956210
- yongyan@goodeepharma.com
- Tel
- 86-21-34053660
- sale@labgogo.com
NUTLIN-3(548472-68-0)Related Product Information
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- NUTLIN-3
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