2-Amino-5-Acetylpyridine Chemical Properties

Boiling point:

332℃

Density 

1.168

Flash point:

155℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

4.76±0.13(Predicted)

Appearance

Light yellow to yellow Solid

2-Amino-5-Acetylpyridine Usage And Synthesis

Synthesis

Step 4 Synthesis of 1-(6-aminopyridin-3-yl)ethanone: To a 1L autoclave was added a saturated aqueous ammonia solution (750 mL) of 1-(6-chloropyridin-3-yl)ethanone (40 g, 257.10 mmol). The reaction mixture was stirred at 130°C for 10 hours. After completion of the reaction, the mixture was cooled and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio 50:1 dichloromethane/methanol) to afford the target compound 1-(6-aminopyridin-3-yl)ethanone in a yield of 33 g in 89% yield as a yellow solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6093 - 6096
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6482 - 6485
[3] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 17; 19
[4] Patent: WO2017/184547, 2017, A1. Location in patent: Paragraph 00379
[5] Patent: US2007/99930, 2007, A1. Location in patent: Page/Page column 45

2-Amino-5-Acetylpyridine(19828-20-7)Related Product Information

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