LEVCROMAKALIM
LEVCROMAKALIM Basic information
- Product Name:
- LEVCROMAKALIM
- Synonyms:
-
- (3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE
- (3s-trans)-yrrolidinyl)
- LEVCROMAKALIM
- 2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p
- brl38227
- lemakalim
- levcromakelim
- (3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran
- CAS:
- 94535-50-9
- MF:
- C16H18N2O3
- MW:
- 286.33
- Mol File:
- 94535-50-9.mol
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LEVCROMAKALIM Chemical Properties
- Melting point:
- 242-244°
- alpha
- D26 -52.2° (c = 1 in chloroform)
- Boiling point:
- 482.3±45.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: ≤10 mM, soluble
- form
- solid
- pka
- 13.18±0.60(Predicted)
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Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- DJ2177500
MSDS
- Language:English Provider:SigmaAldrich
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LEVCROMAKALIM Usage And Synthesis
Uses
Anti-asthmatic; antihypertensive.
Uses
Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus.
Definition
ChEBI: Levcromakalim is a 1-benzopyran.
Biological Activity
Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.
storage
Store at RT
LEVCROMAKALIMSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
EMMX Biotechnology LLC
- Tel
- 888-539-0666
- info@emmx.com
Changzhou PBpharmaceutical R&D Co.,Ltd
- Tel
- 0519-83990708
- lxy2046@yeah.net
Shenzhen Regent Biochemical Technology Co., Ltd.
- Tel
- 0755-0755-85201366 18938635012
- sales@regentsciences.com
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LEVCROMAKALIM(94535-50-9)Related Product Information
- 4-TERT-BUTOXYBENZONITRILE
- 3-(methylaminomethyl)benzonitrile
- LEVCROMAKALIM
- 3-M-TOLYL-DL-BETA-ALANINOL
- 3-CYANOBENZYLAMINE
- (S)-3-Dimethylamino-3-phenylpropanol
- 1-Benzyl-2-pyrrolidinone
- CROMAKALIM
- (S)-3-(1-Aminoethyl)benzonitrile
- 4-(2-hydroxyethoxy)benzonitrile
- 2-(3-CYANO-PHENYL)ETHANOL
- (2S)-(-)-1-AMINO-3-PHENOXY-2-PROPANOL
- 4-isopropoxybenzonitrile
- 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE
- 3-PYRROLIDINO-1,2-PROPANEDIOL
- 1-(3-METHOXYPROPYL)-2-PYRROLIDINONE
- 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE
- 4-[3-(Dimethylamino)propoxy]benzonitrile