BUTTPARK 146\18-29 Chemical Properties

Melting point:

195-200℃ (ethanol )

Boiling point:

406.7±33.0 °C(Predicted)

Density 

1.53±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

11.56±0.20(Predicted)

Appearance

Off-white to light brown Solid

Safety Information

Risk Statements 

20/21/22

Safety Statements 

3/7-36/37

HS Code 

29335990

BUTTPARK 146\18-29 Usage And Synthesis

Chemical Properties

Yellow solid

Synthesis

General procedure for the synthesis of 6-methyl-3H-thieno[2,3-d]pyrimidin-4-one from ethyl 2-amino-5-methylthiophene-3-carboxylate (2.3 g, 12.0 mmol) and formamide (28 mL): a suspension of ethyl 2-amino-5-methylthiophene-3-carboxylate and formamide was heated and reacted for 16 hours at 180 °C. Upon completion of the reaction, the reaction mixture was quenched with 100 mL of water and stirring was continued for 30 minutes. The precipitated solid was collected by filtration, washed with pentane and dried by filtration to give 6-methyl-3H-thieno[2,3-d]pyrimidin-4-one (1.0 g, crude) as an off-white solid. Results of mass spectrometry analysis: calculated value (M + H): 167.02; measured value (M + H): 167.1.

References

[1] Pharmaceutical Chemistry Journal, 1987, vol. 21, # 2, p. 126 - 129
[2] Khimiko-Farmatsevticheskii Zhurnal, 1987, vol. 21, # 2, p. 197 - 200
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 3, p. 870 - 876
[4] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 148 - 160
[5] Patent: WO2017/100599, 2017, A1. Location in patent: Paragraph 00125-00126

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