ChemicalBook > Product Catalog > Biochemical Engineering > Amino Acids and Derivatives > Tryptophan derivatives > A-METHYL-L-TRYPTOPHAN
A-METHYL-L-TRYPTOPHAN
A-METHYL-L-TRYPTOPHAN Basic information
- Product Name:
- A-METHYL-L-TRYPTOPHAN
- Synonyms:
-
- (S)-A-METHYLTRYPTOPHAN
- ALPHA-ME-DL-TRYPTOPHAN
- ALPHA-METHYL-DL-TRYPTOPHAN
- A-METHYL-L-TRYPTOPHAN
- DL-2-METHYL-2-AMINO-3-(3-INDOLYL)PROPIONIC ACID
- DL-ALPHA-METHYLTRYPTOPHAN
- H-ALPHA-ME-DL-TRP-OH
- H-DL-(ME)TRP-OH
- CAS:
- 153-91-3
- MF:
- C12H14N2O2
- MW:
- 218.26
- Product Categories:
-
- Amino Acids
- I - Z
- Modified Amino Acids
- Mol File:
- 153-91-3.mol
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A-METHYL-L-TRYPTOPHAN Chemical Properties
- Melting point:
- 234 °C(Solv: ethanol, 60% (64-17-5))
- Boiling point:
- 444.0±35.0 °C(Predicted)
- Density
- 1.314±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- crystalline
- pka
- 2.34±0.10(Predicted)
- color
- light yellow
MSDS
- Language:English Provider:SigmaAldrich
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A-METHYL-L-TRYPTOPHAN Usage And Synthesis
Chemical Properties
White to off-white powder
Uses
α-methyl-DL-tryptophan is used as a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer. It is also a substrate or non-transported inhibitor of the amino acid transporter PAT2 (slc36a2).
Biochem/physiol Actions
α-methyl-DL-tryptophan is a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer.
in vivo
α-Methyl-DL-tryptophan (α-MT) (2 mg/mL; administered in drinking water; continuously administered; throughout the experimental period) inhibits tumor growth in BALB/c nude mice inoculated with ZR-75-1 cells[1].
α-Methyl-DL-tryptophan (1 mg/mL; administered in drinking water; continuously administered; for 1 week) reduces body weight in wild-type mice on a high-fat diet[2].
| Animal Model: | BALB/c nude mice (female) inoculated with ZR-75-1 cells[1] |
| Dosage: | 2 mg/mL |
| Administration: | Administered in drinking water |
| Result: | Reduced the growth of ZR-75-1 cells. Tumor size was significantly smaller than that in the control group. |
| Animal Model: | Wild-type C57BL/6 male mice fed a high-fat diet[2] |
| Dosage: | 1 mg/mL |
| Administration: | Administered in drinking water, continuously for 1weeks |
| Result: | Led to a decrease in body weight. |
A-METHYL-L-TRYPTOPHANSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Shanghai Hanhong Scientific Co.,Ltd.
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
- shchemsky@sina.com
Hunan Hui Bai Shi Biotechnology Co., Ltd.
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
- Tel
- 025-66113011 17798518460
- cfzhang@aikonchem.com
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A-METHYL-L-TRYPTOPHAN(153-91-3)Related Product Information
- ALPHA-METHYL-L-TRYPTOPHAN,α-Methyl-(S)-tryptophan
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- H-VAL-ALA-OH
- ALPHA-METHYL-L-VALINE HYDROCHLORIDE
- H-VAL-VAL-OH
- L-VALINE TERT-BUTYL ESTER HYDROCHLORIDE
- L-Valine methyl ester hydrochloride
- L-Valine benzyl ester 4-toluenesulfonate
- ALPHA-METHYL-DL-HISTIDINE DIHYDROCHLORIDE
- H-α-Me-Tyr(tBu)-OH
- H-VAL-TYR-OH
- H-VAL-NH2 HCL
- H-ALPHA-ME-D-VAL-OH
- Dipeptide-2
- 5-METHYL-DL-TRYPTOPHAN
- DL-Tryptophan