Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI) Chemical Properties

Boiling point:

246.7±20.0℃ (760 Torr)

Density 

1.175±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

103.0±21.8℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-2.23±0.10(Predicted)

Appearance

White to light yellow Solid

Safety Information

HS Code 

2933399990

Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI) Usage And Synthesis

Synthesis

To a cold solution (-78°C) of 6-fluoro-N-methoxy-N-methylnicotinamide (Method 38, 7.2 g, 39 mmol) in tetrahydrofuran (130 mL) was added slowly and dropwise methylmagnesium bromide (20 mL, 59 mmol, 3 M ether solution). The cooling bath was removed and the reaction mixture was allowed to gradually warm to room temperature with continuous stirring for 2 hours. Upon completion of the reaction, the reaction was quenched with 3 N hydrochloric acid solution and the layers were separated. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 3.8 g of 2-fluoro-5-acetylpyridine in 70% yield. The product was characterized by 1H NMR (CDCl3): δ 8.80 (s, 1H), 8.29-8.43 (m, 1H), 6.98-7.06 (m, 1H), 2.62 (s, 3H).

References

[1] Patent: WO2006/82392, 2006, A1. Location in patent: Page/Page column 116
[2] Patent: US2017/313683, 2017, A1. Location in patent: Paragraph 1251-1252

Ethanone, 1-(6-fluoro-3-pyridinyl)- (9CI)(84331-14-6)Related Product Information

• 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE
• 2-Chloro-5-acetylpyridine