6,7-dimethylisatin Chemical Properties

Melting point:

252 °C

Density 

1.250±0.06 g/cm3(Predicted)

pka

10.43±0.20(Predicted)

6,7-dimethylisatin Usage And Synthesis

Uses

6,7-Dimethylisatin (compound 1l), an Isatin (HY-Y0265) analogue, is a potent MAO inhibitor with IC50s of 20.3 μM and 6.74 μM for MAO-A and MAO-B, respectively. 6,7-Dimethylisatin has the potential for depression, Alzheimer's disease and Parkinson's disease research[1].

IC 50

MAO-A: 20.3 μM (IC₅₀); MAO-B: 6.74 μM (IC₅₀)

References

[1] Izak F Prinsloo, et al. The evaluation of isatin analogues as inhibitors of monoamine oxidase. Chem Biol Drug Des. 2023 Nov;102(5):1067-1074. DOI:10.1111/cbdd.14304

6,7-dimethylisatin(20205-43-0)Related Product Information

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• Ethanone, 1-(2-amino-3,4-dimethylphenyl)- (9CI)
• 2-AMINO-4-METHYLBENZALDEHYDE
• 6,7-dimethylisatin
• 7-METHYL-2,3-DIHYDRO-1H-INDOLE
• N-(2,3-DIMETHYLPHENYL)ACETAMIDE
• 2-(4-methylphenyl)acetamide