sorivudine Chemical Properties

Melting point:

182° (Sakata, 1980); mp 195-200° (dec) (Machida, Sakata, 1983)

alpha 

D25 +0.5° (1N NaOH)

Density 

1.979±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 250 mg/mL (716.07 mM)

form 

Solid

pka

8.37±0.10(Predicted)

color 

White to off-white

Safety Information

Toxicity

LD50 in mice (mg/kg): ~3300 i.p.; >5000 s.c.; >10000 orally (Machida, Sakata, 1984)

sorivudine Usage And Synthesis

Description

Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of 20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream is also useful in the topical treatment of cutaneous HSV-1 infection, including immunocompromised patients. It has been suggested that its antiviral activity may be mediated by inhibition of DNA synthesis in virus infected cells.
Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism, caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to avoid hematological disorders.

Originator

Yamasa Shoyu (Japan)

Uses

Sorivudine is an antimetabolite drug and can be used to synthesize antiviral compounds as well as compounds that can treat diseases of viral etiol.

Uses

Antiviral.

Definition

ChEBI: Sorivudine is an organic molecular entity.

brand name

Bravavir (Bristol-Myers Squibb);Usevir.

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