Methoxy-PEG-propionicacid-N-succinimidylester Chemical Properties

storage temp. 

-20°C

solubility 

Soluble in DMSO, DCM, DMF

form 

solid

color 

white to off-white

α-end

methoxy

Ω-end

NHS ester

InChI

InChI=1S/C10H15NO6/c1-15-6-7-16-5-4-10(14)17-11-8(12)2-3-9(11)13/h2-7H2,1H3

InChIKey

IMSXKORGOVQCNT-UHFFFAOYSA-N

SMILES

O(N1C(CCC1=O)=O)C(=O)CCO{-}CC{+n}OC

Methoxy-PEG-propionicacid-N-succinimidylester Usage And Synthesis

Description

m-PEG12-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reagent type: chemical modification reagent
reactivity: amine reactive

IC 50

PEGs

References

[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

Methoxy-PEG-propionicacid-N-succinimidylester(174569-25-6)Related Product Information

• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• METHYL ISOCYANOACETATE
• Benzyl isocyanide
• Ferric acetylacetonate
• TERT-BUTYL ISOCYANIDE
• COBALT(II) ACETYLACETONATE
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• N-BUTYLISOCYANIDE
• PHENYLSELENOL
• Tris(2,4-pentanedionato)chroMiuM(III)
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• SALCOMINE
• Ethyl isocyanoacetate
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Cupric acetylacetonate
• Aluminum acetylacetonate
• Tosylmethyl isocyanide
• 2,4-PENTANEDIONE, SILVER DERIVATIVE