4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Chemical Properties

Melting point:

179-183 °C

Boiling point:

241.0±50.0 °C(Predicted)

Density 

2.47±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

9.61±0.20(Predicted)

color 

White to Orange to Green

Water Solubility 

Insoluble in water.

Sensitive 

Light Sensitive

λmax

305nm(H2O)(lit.)

InChIKey

CBWBJFJMNBPWAL-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-R36/37/38-R22

Safety Statements 

26-36/37-S36/37-S26-37

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29335990

4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Usage And Synthesis

Uses

6-Chloro-7-iodo-7-deazapurine is used as pharmaceutical intermediate.

Definition

4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine, also known as 6-Chloro-7-iodo-7-deazapurine or 4-Chloro-5-iodo-1H-pyrrolo[2,3-d]pyrimidine, is a white solid that can be obtained by iodine reaction of 4-chloro-7h-pyrrole [2,3-d] pyrimidine with NIS.

Synthesis

4-chloro-7h-pyrrole [2,3-d] pyrimidine (8.0 g, 52.32 mmol, 1.0 eq) was dissolved in DMF(40 mL) and NIS(15.7g, 57.55 mmol, 1.1eq) was added at 0℃. After stirring at room temperature overnight, 200 mL of saturated Na2S2O3 solution was added. The mixture was filtered, washed with water three times, and vacuum drying, to obtain 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine.

4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine(123148-78-7)Related Product Information

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