1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXAMIDE Chemical Properties

Melting point:

164 °C

Boiling point:

288.7±28.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

15.55±0.50(Predicted)

Appearance

White to off-white Solid

CAS DataBase Reference

136678-93-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25-36-26

Hazard Note 

Irritant

HS Code 

29331990

1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXAMIDE Usage And Synthesis

Chemical Properties

White crystal

Synthesis

Example 47: Synthesis of 1,3-dimethyl-1H-pyrazole-5-carboxamide; Ethyl 1,3-dimethyl-1H-pyrazole-5-carboxylate (9.5 g, 56.5 mmol, 1.0 eq.) was dissolved in an aqueous solution of ammonium hydroxide and the reaction was stirred for 16.5 hours at room temperature. Upon completion of the reaction, the organic layer was extracted with a 10% isopropanol/chloroform solvent mixture, followed by washing the organic layer with saturated aqueous sodium chloride solution and drying with anhydrous magnesium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give a white solid product (6.0 g, 77% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.78 (s, 1H), 7.38 (s, 1H), 6.59 (s, 1H), 3.94 (s, 3H), 2.12 (s, 3H). lC-MS (ESI+) analysis showed that m/z 140 corresponded to the [M+H]+ ion of C6H9N3O.

References

[1] Patent: WO2006/43145, 2006, A1. Location in patent: Page/Page column 91

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