3-CHLORO-2-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2928009090

3-CHLORO-2-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE Usage And Synthesis

Synthesis

The general procedure for synthesizing 2,3-difluorophenylhydrazine hydrochloride from 2,3-difluoroaniline was as follows: to an aqueous solution (100 mL) of sodium nitrite (27.8 g), a concentrated hydrochloric acid solution (620 mL) of 2,3-difluoroaniline (40 g) was added slowly and dropwise at -20° C. The reaction mixture was stirred for 1 hour. The reaction mixture was kept stirred at -20°C for 1 hour. Subsequently, a concentrated hydrochloric acid (200 mL) solution of tin(II) chloride (117 g) was added slowly and dropwise at the same temperature, and then the reaction mixture was warmed up to 0 °C and stirring was continued for 2 hours. Upon completion of the reaction, the resulting solid product was collected by filtration, washed sequentially with water and hexane, and finally concentrated and dried under reduced pressure to afford the target compound 2,3-difluorophenylhydrazine hydrochloride as a white solid (32.6 g, 73% yield). The structure of the product was confirmed by 1H-NMR (DMSO-d6), δ: 6.96-7.19 (3H, m), 8.70 (1H, brs), 10.66 (3H, brs).

References

[1] Patent: US2009/156642, 2009, A1. Location in patent: Page/Page column 66

3-CHLORO-2-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE(60481-38-1)Related Product Information

• 2-Fluorophenylhydrazine hydrochloride
• 2-Fluorophenylhydrazine