5-Pyrimidinecarboxylic acid Chemical Properties

Melting point:

259 °C

Boiling point:

318.7±15.0 °C(Predicted)

Density 

1.403±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

2.74±0.10(Predicted)

form 

Solid

color 

White to Yellow to Orange

λmax

275nm(H2O)(lit.)

InChIKey

IIVUJUOJERNGQX-UHFFFAOYSA-N

CAS DataBase Reference

4595-61-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36

Safety Statements 

22-26-36/37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29335990

5-Pyrimidinecarboxylic acid Usage And Synthesis

Chemical Properties

White to off-white solid

Uses

Pyrimidine-5-carboxylic Acid is used in the preparation of heterocyclic compounds as an antiviral agent.

Synthesis

General procedure for the synthesis of pyrimidine-5-carboxylic acid from ethyl pyrimidine-5-carboxylate: 19.50 mL (149 mmol) of ethyl pyrimidine-5-carboxylate was mixed with 40 mL of 4 M sodium hydroxide solution at room temperature, and the reaction was oscillated for 0.1 hour. Subsequently, 40 mL of 4 M hydrochloric acid solution was added for neutralization. The precipitate formed in the reaction was separated by filtration, washed with petroleum ether and then dried. Finally, 14.80 g of pyrimidine-5-carboxylic acid was obtained in a yield of 80% of the theoretical value.

References

[1] Patent: US2007/259855, 2007, A1. Location in patent: Page/Page column 17-18

5-Pyrimidinecarboxylic acid(4595-61-3)Related Product Information

• Silver sulfadiazine
• Sulfadiazine
• Cytosine
• Folic acid
• EPA
• Pyrimidine
• Fluorocytosine
• Uracil
• 5-Pyrimidinecarboxylic acid, methyl ester (6CI,7CI,8CI,9CI)
• 2-Pyrimidinecarboxylic acid(Crystalline solid)
• PYRIMIDINE-4-CARBOXYLIC ACID METHYL ESTER
• 2-Pyrimidinecarboxamide (6CI,7CI,9CI)
• Pyrimidine-5-boronic acid pinacol ester
• PYRIMIDINE-4-CARBOXALDEHYDE
• Pyrimidine-5-carboxaldehyde
• Citric acid
• Ascoric Acid
• 4-Chloro-(2-methylthio)-5-pyrimidinecarboxylic acid ethyl ester