2,4-Dibromo-1-nitrobenzene Chemical Properties

Melting point:

61-62℃

Boiling point:

270℃

Density 

2.101

refractive index 

1.6400 (estimate)

Flash point:

117℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

Crystalline Powder

color 

Yellow

InChIKey

DXRVYZGVVFZCFP-UHFFFAOYSA-N

Safety Information

HS Code 

2904.99.4700

HazardClass 

6.1

2,4-Dibromo-1-nitrobenzene Usage And Synthesis

Description

2,4-Dibromo-1-nitrobenzene is a pharmaceutical intermediate that can be obtained by nitration of m-dibromobenzene. This compound can be used to prepare the benzimidazole anthelmintic fenbendazole through a four-step reaction.

Chemical Properties

Light yellow powder

Production Methods

Dissolve 24.5g of m-dibromobenzene in 49.0g of concentrated sulfuric acid (98%) at room temperature, cool to 0-5°C, add 9.80g of nitric acid (68%) dropwise, control the temperature at 0-5°C during the addition process, and stir at 5-10°C for 2 hours after the addition is complete. After the reaction is completed, add the reaction solution dropwise to 49.0g of cold water, and the temperature does not exceed 60°C during the quenching process. After the quenching is completed, stir at room temperature for 0.5 hours, filter, and wash the filter cake with 15.0g of water to obtain 31.95g (water content 16.0%) of 2,4-Dibromo-1-nitrobenzene tide product with a purity of 99.75%.

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