4-Phenylcyclohexanone Chemical Properties

Melting point:

73-77 °C (lit.)

Boiling point:

158-160°C 16mm

Density 

0.97 g/cm3 (25℃)

refractive index 

1.5363 (estimate)

Flash point:

100°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol

form 

Crystalline Powder

color 

White to off-white

Water Solubility 

slightly soluble

BRN 

2045904

CAS DataBase Reference

4894-75-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

22-24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29143900

MSDS

• Language:English Provider:4-Phenylcyclohexanone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Phenylcyclohexanone Usage And Synthesis

Chemical Properties

white to off-white crystalline powder

Uses

4-Phenylcyclohexanone is used in the synthesis of CCR2 antagonists for the treatment of rheumatoid arthritis, atherosclerosis and other disease states. Also used in the preparation of coumarins via dehydrogenation and Heck coupling reactions.

Uses

4-Phenylcyclohexanone was used in the preparation of new cardo diamine monomer, 1,1-bis[4-(4-aminophenoxy)phenyl]-4-phenylcyclohexane bearing a 4-phenylcyclohexylidene unit.

General Description

4-Phenylcyclohexanone undergoes Ruthenium-catalyzed reaction with tributylamine to yield 2-butyl-4-phenylcyclohexanone and 2,6-dibutyl-4-phenylcyclohexanone. Wittig reaction of 4-phenylcyclohexanone with (carbethoxymethylene)triphenylphosphorane under microwave irradiation has been investigated.

4-Phenylcyclohexanone(4894-75-1)Related Product Information

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