2-AMINO-THIAZOLE-4-CARBOXYLAMIDE Chemical Properties

Melting point:

>195°C (dec.)

Boiling point:

460.3±18.0 °C(Predicted)

Density 

1.537±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMSO (Slightly, Sonicated), Methanol (Slightly)

form 

Solid

pka

15.14±0.50(Predicted)

color 

Pale Beige

2-AMINO-THIAZOLE-4-CARBOXYLAMIDE Usage And Synthesis

Uses

2-Aminothiazole-4-carboxamide is a useful intermediate for organic synthesis and other chemical processes.

Synthesis

General procedure for the synthesis of 2-aminothiazole-4-carboxylic acid from ethyl 2-aminothiazole-4-carboxylate: 3.0 g of ethyl 2-aminothiazole-4-carboxylate was dissolved in 100 mL of ammonia, and the reaction was stirred for 2 hours at room temperature. Upon completion of the reaction, the reaction solution was concentrated to dryness and left to precipitate needle-like crystals. The crystals were collected by filtration and washed several times with cold water to remove impurities. Finally, the product was dried at room temperature to give 1.9 g of 2-aminothiazole-4-carboxamide in 76% yield with a melting point of 208-211 °C.

References

[1] Patent: EP2039686, 2009, A1. Location in patent: Page/Page column 23
[2] Patent: US2010/87448, 2010, A1. Location in patent: Page/Page column 15
[3] Patent: US2006/63814, 2006, A1. Location in patent: Page/Page column 62

2-AMINO-THIAZOLE-4-CARBOXYLAMIDE (118452-02-1)Related Product Information

• 5-Thiazolecarboxamide,2-amino-(9CI)
• 2-Aminothiazole
• THIAZOLE-4-CARBOXAMIDE
• Nifuralide
• TOSLAB 12784
• N'-[(E)-(3-METHOXYPHENYL)METHYLIDENE]-2-[3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-1,3-THIAZOLE-4-CARBOHYDRAZIDE
• 2-AMINO-1,3-THIAZOLE-4-CARBOHYDRAZIDE
• 2-[5-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-N'-[(1E)-PYRIDIN-3-YLMETHYLENE]-1,3-THIAZOLE-4-CARBOHYDRAZIDE
• (E)-N'-(4-(DIETHYLAMINO)BENZYLIDENE)-2-(5-(NAPHTHALEN-2-YL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)THIAZOLE-4-CARBOHYDRAZIDE
• (E)-N'-(4-(DIMETHYLAMINO)BENZYLIDENE)-2-(5-(NAPHTHALEN-2-YL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)THIAZOLE-4-CARBOHYDRAZIDE
• (E)-N'-(4-(DIETHYLAMINO)BENZYLIDENE)-2-(5-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)THIAZOLE-4-CARBOHYDRAZIDE
• (E)-N'-(4-(BIS(2-CHLOROETHYL)AMINO)BENZYLIDENE)-2-(5-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL)THIAZOLE-4-CARBOHYDRAZIDE
• N'-[(E)-(4-METHOXYPHENYL)METHYLIDENE]-2-[3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-1,3-THIAZOLE-4-CARBOHYDRAZIDE
• N'-FORMYL-2-[3-(2-NAPHTHYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-1,3-THIAZOLE-4-CARBOHYDRAZIDE
• 2-AMINO-5-PHENYL-1,3-THIAZOLE-4-CARBOHYDRAZIDE
• N-(5-fluorobenzothiazol-2-yl)-2-guanidinothiazole-4-carboxamide
• 2-[3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-N'-[(E)-3-PYRIDINYLMETHYLIDENE]-1,3-THIAZOLE-4-CARBOHYDRAZIDE
• N'-ACETYL-2-[5-PHENYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-1,3-THIAZOLE-4-CARBOHYDRAZIDE