Basic information Safety Supplier Related

Erythromycin A Oxime

Basic information Safety Supplier Related

Erythromycin A Oxime Basic information

Product Name:
Erythromycin A Oxime
Synonyms:
  • (9E)-ErythroMycin A OxiMe
  • Erythromycin A Oxime
  • (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-10-(hydroxyimino)-3,5,7,9
  • Azithromycin Impurity S ((9E)-Erythromycin A Oxime)
  • (9E)-Erythromycin A Oxime Roxithromycin EP Impurity C
  • Roxithromycin EP Impurity C (Erythromycin Impurity J)
  • Erythromycin Impurity J
  • (3R,4S,5S,6R,7R,9R,11S,12R,13S,14R,E)-6-(((2R,3R,4S,6R)- 4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2- yl)oxy)-14-ethyl-7,12,13-trihydroxy-4-(((2R,4R,5S,6S)-5- hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl) oxy)-10-(hydroxyimino)-3,5,7,9,11,13-hexamethyl oxacyclotetradecan-2-one
CAS:
111321-02-9
MF:
C37H68N2O13
MW:
748.95
Product Categories:
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:
111321-02-9.mol
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Erythromycin A Oxime Chemical Properties

Melting point:
156-166 °C
Boiling point:
841.0±65.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
11.96±0.70(Predicted)
color 
White to Off-White
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Erythromycin A Oxime Usage And Synthesis

Description

(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin .

Chemical Properties

Off-White Solid

Uses

Intermediate of Azithromycin. Antibacterial agent.

Uses

(9E)-Erythromycin A Oxime is a metabolite of Roxithromycin (R700850) in humans. It has anti-Helicobacter pylori activity

Uses

Erythromycin A 9-oxime is a semi-synthetic analogue of erythromycin prepared as means of overcoming acid lability and improving oral absorption of erythromycin A while retaining comparable antibacterial and potency. Although not developed as a commercial product, erythromycin oxime was pivotal in the development of the ring expanded aza-erythromycins (e.g. azithromycin) and the oxime ethers (e.g. roxithromycin).

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