2-Amino-5-chloro-3-fluoropyridine Chemical Properties

Melting point:

91-95 °C

Boiling point:

195.9±35.0 °C(Predicted)

Density 

1.449±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

solid

pka

1.72±0.49(Predicted)

Appearance

White to light brown Solid

Safety Information

Hazard Codes 

T,Xi

Risk Statements 

23/24/25-50

Safety Statements 

36/37-38-45-61-63

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

2

HazardClass 

IRRITANT

HS Code 

29333990

2-Amino-5-chloro-3-fluoropyridine Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-amino-3-fluoro-5-chloropyridine from 2,3-difluoro-5-chloropyridine: 5-chloro-2,3-difluoropyridine (100 g, 0.669 mol) and liquid ammonia (1.125 L, 8.025 mol) were placed in an autoclave. The kettle was sealed and the reaction was carried out at 120 °C for 24 hours. Upon completion of the reaction, the reaction mixture was cooled and formation of a yellowish solid precipitate was observed. The precipitate was separated by filtration and the filter cake was washed with deionized water. The filtrate was extracted with ethyl acetate, the organic layers were combined and dried with anhydrous sodium sulfate. Subsequently, the organic solvent was removed by distillation under reduced pressure, and a small amount of petroleum ether was added to the residue, which was filtered again to obtain a precipitate of the target compound 2-amino-3-fluoro-5-chloropyridine. The final product was obtained as 84.22 g in 85.94% yield.

References

[1] Patent: CN105669539, 2016, A. Location in patent: Paragraph 0058; 0059; 0060
[2] Patent: US2008/242695, 2008, A1. Location in patent: Page/Page column 34
[3] Patent: US2008/242695, 2008, A1. Location in patent: Page/Page column 34

2-Amino-5-chloro-3-fluoropyridine(246847-98-3)Related Product Information

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