Dehydroevodiamine
Dehydroevodiamine Basic information
- Product Name:
- Dehydroevodiamine
- Synonyms:
-
- Dehydroevodiamine
- 14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-14-ium
- 5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium
- 8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt
- 14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide
- Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt
- dehydrovodiamine
- 14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium-13-ide
- CAS:
- 67909-49-3
- MF:
- C19H15N3O
- MW:
- 301.35
- EINECS:
- 200-258-5
- Product Categories:
-
- reagent
- standard substance
- Mol File:
- 67909-49-3.mol
Dehydroevodiamine Chemical Properties
- Melting point:
- 190-192℃
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- powder
- color
- Yellow
Dehydroevodiamine Usage And Synthesis
Chemical Properties
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus.
Uses
Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo.
Biological Activity
Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages.
Physiological effects
Dehydroevodiamine has an antihypertensive and antitumor effects.
in vitro
Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression.
Western Blot Analysis
| Cell Line: td> | RAW 264.7 macrophage cells |
| Concentration: | 10 μM, 30 μM, 50 μM |
| Incubation Time: | pretreated 2 hours |
| Result: | Reduced iNOS and COX-2 expression and increased IκB-α expression. |
RT-PCR
| RAW 264.7 macrophage cells | |
| Concentration: | 10 μM, 30 μM, 50 μM | td>
| Incubation Time: | pretreated 2 hours |
| Result: | Reduced iNOS and COX-2 mRNA expression. |
target
| Target | Value |
| NF-κB () | |
| COX-2 () | |
| iNOS () | |
| PGE2 () |
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