Phenetole Chemical Properties

Melting point:

−30 °C(lit.)

Boiling point:

169-170 °C(lit.)

Density 

0.966 g/mL at 25 °C(lit.)

vapor pressure 

2.266hPa at 25℃

refractive index 

n20/D 1.507(lit.)

Flash point:

135 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

alcohol: freely soluble(lit.) Insoluble in water, soluble in alcohol and oils.

form 

Liquid

pka

0[at 20 ℃]

color 

Clear colorless to very slightly yellow

Relative polarity

2.9

Water Solubility 

PRACTICALLY INSOLUBLE

Sensitive 

Light Sensitive

Merck 

14,7229

BRN 

636270

Dielectric constant

4.2（20℃）

InChIKey

DLRJIFUOBPOJNS-UHFFFAOYSA-N

LogP

2.041 at 23℃

CAS DataBase Reference

103-73-1(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, ethoxy-(103-73-1)

EPA Substance Registry System

Benzene, ethoxy- (103-73-1)

Safety Information

Hazard Codes 

F,C

Risk Statements 

10-34-11

Safety Statements 

24/25-45-36/37/39-26-16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

2

RTECS 

SI7700000

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29093090

Hazardous Substances Data

103-73-1(Hazardous Substances Data)

Toxicity

MLD in rats (mg/kg): 3500-4000 s.c. (Binet)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Phenetole Usage And Synthesis

Description

Phenetole is a colorless liquid which is prepared by etherification of phenol with ethyl chloride or diethyl sulfate. Phenyl ethyl ether is an intermediate in numerous organic syntheses.

Chemical Properties

CLEAR COLOURLESS TO VERY SLIGHTLY YELLOW LIQUID

Uses

Ethoxybenzene (Phenetole) was used as an analyte in assaying the performance of the porous graphitic carbon (PGC) particles.

Definition

ChEBI: An aromatic ether in which the ether oxygen is bonded to an ethyl and a phenyl group.

Synthesis Reference(s)

The Journal of Organic Chemistry, 55, p. 358, 1990 DOI: 10.1021/jo00288a065
Tetrahedron Letters, 29, p. 5553, 1988 DOI: 10.1016/S0040-4039(00)80811-4

Flammability and Explosibility

Non flammable

Synthesis

Phenetole is produced from Phenol and Diethylsulfate in weak aqueous alkaline solution.

Purification Methods

Small quantities of phenol can be removed by shaking with NaOH, but this is not a very likely contaminant of commercial material. Fractional distillation from sodium, at low pressures, probably gives adequate purification. It can be dissolved in diethyl ether and washed with 10% NaOH (to remove phenols), then water. The ethereal solution is evaporated, and the phenetole is fractionally distilled under vacuum. [Beilstein 6 H 140, 6 I 80, 6 II 142, 6 III 545.]

Phenetole(103-73-1)Related Product Information

• Ethylparaben
• 4-Ethoxybenzaldehyde
• 2,2-Diethoxyacetophenone
• 2-Ethoxybenzoic acid
• 2,3-DIFLUOROETHOXYBENZENE
• Methylphenyldiethoxysilane
• PHENYL VALERATE
• DIETHOXYMETHANE
• 2-Ethoxybenzoyl chloride
• Diphenyl ether
• Phenyl salicylate
• 2-Ethoxyethanol
• Ethoxyquin
• Ethylbenzene
• Ethoxyethyne
• Ethoxyamine hydrochloride
• Boron trifluoride diethyl etherate
• 4'-Ethoxyacetophenone