Romifidine hydrochloride Chemical Properties

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White

InChI

InChI=1S/C9H9BrFN3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

InChIKey

SDXVSIWCVTYYQN-UHFFFAOYSA-N

SMILES

C1(NC2=C(F)C=CC=C2Br)NCCN=1.[H]Cl

Romifidine hydrochloride Usage And Synthesis

Description

Romifidine hydrochloride [N-(2-b romifidineo-6-fluoro-phenyl)- 4,5-dihydro-1H-imidazol-2-amine mono-hydrochloride, C9H9BrFN3, MW 258.1; romifidine] is an imidazole derivative with potent a2-adrenoceptor agonist properties. It is commonly used in equine practice to provide sedation, analgesia, and muscle relaxation. A comparative study reported that an intravenous (i.v.) dose of 80 μg/kg romifidine is equipotent to 1 mg/kg xylazine i.v. and 20 μg/kg detomidine i.v.[1]. Typical signs of sedation include muscle relaxation, decreased head height (HH), diminished responsiveness to external stimuli, and postural abnormalities following romifidine administration. Furthermore, romifidine possesses antinociceptive activity. As an analgesic, it reduces anesthetic requirements for isoflurane in horses.

Uses

An α2 agonist use as a sedative and analgesic.

Uses

As an α2 agonist used as a sedative and analgesic, RoMifidine Hydrochloride is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses.

Mechanism of action

Alpha2 agonists decrease release of neurotransmitters from the neuron. The proposed mechanism whereby they decrease transmission is via binding to presynaptic alpha2 receptors (negative feedback receptors).

References

[1] M. WOJTASIAK-WYPART. “Pharmacokinetic profile and pharmacodynamic effects of romifidine hydrochloride in the horse.” Journal of veterinary pharmacology and therapeutics 35 5 (2012): 478–488.

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