Methyl piperidine-4-carboxylate hydrochloride Chemical Properties

Melting point:

160°C

Boiling point:

85-90 °C

Density 

1.06

refractive index 

1.465

Flash point:

89 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to off-white Solid

CAS DataBase Reference

7462-86-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

Methyl piperidine-4-carboxylate hydrochloride Usage And Synthesis

Uses

Methyl piperidine-4-carboxylate hydrochloride is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

General procedure for the synthesis of methyl 4-piperidinecarboxylate hydrochloride from methyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate: To a dichloromethane (DCM, 3 mL) solution of methyl 1-tert-butoxycarbonyl-4-piperidinecarboxylate (2.16 g, 8.88 mmol) was added a solution of ethyl acetate (EtOAc, 6 mL) of 4 M hydrochloric acid. The reaction mixture was stirred at room temperature for 1.5 h. Subsequent removal of the solvent by concentration under reduced pressure afforded methyl 4-piperidinecarboxylate hydrochloride as a white solid (1.59 g, 99% yield). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 3.73 (s, 3H), 3.44-3.39 (m, 2H), 3.15-3.09 (m, 2H), 2.82-2.77 (m, 1H), 2.21-2.16 (m, 2H), 1.99-1.89 (m, 2H); MS-ESI: m/z 144.2 [M + H - HCl]+.

References

[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00373
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 0920-0923

Methyl piperidine-4-carboxylate hydrochloride (7462-86-4)Related Product Information

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