Oxetan-3-ol
Oxetan-3-ol Basic information
- Product Name:
- Oxetan-3-ol
- Synonyms:
-
- 3-Oxetanol
- Ooetan-3-ol
- Oxetan-3-ol, 1,3-Epoxypropan-2-ol
- 3-Hydroxyoxetane 95%
- 3 - hydroxyl oxygen heterocyclic butane
- 1,3-Epoxy-2-propanol
- Oxetan-3-ol, >=97%
- Oxetan-3-ol
- CAS:
- 7748-36-9
- MF:
- C3H6O2
- MW:
- 74.08
- EINECS:
- 663-648-9
- Product Categories:
-
- API intermediates
- Alcohols and Derivatives
- Heterocycles
- Building Blocks/Intermediates
- Pyridines
- 1
- Mol File:
- 7748-36-9.mol
Oxetan-3-ol Chemical Properties
- Boiling point:
- 153℃
- Density
- 1.167
- refractive index
- 1.438
- Flash point:
- 87°(189°F)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Soluble), Methanol (Slightly)
- pka
- 13.68±0.20(Predicted)
- form
- Liquid
- color
- Clear colorless
- InChI
- InChI=1S/C3H6O2/c4-3-1-5-2-3/h3-4H,1-2H2
- InChIKey
- QMLWSAXEQSBAAQ-UHFFFAOYSA-N
- SMILES
- O1CC(O)C1
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- RIDADR
- NA 1993 / PGIII
- WGK Germany
- 3
- TSCA
- No
- HS Code
- 29329990
Oxetan-3-ol Usage And Synthesis
Chemical Properties
Colorless Transparent Liquid
Uses
3-Oxetanol is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.
Synthesis
95257-22-0
7748-36-9
General procedure for the synthesis of oxetan-3-ol from 3-(phenylmethoxy)oxetane: 3-(phenylmethoxy)oxetane (59 g, 0.41 mol) and 10% palladium/carbon catalyst were added to methanol (1000 mL) in an autoclave. The hydrogenation reaction was completed by reacting under hydrogen atmosphere (10 atm) at 40°C for 24 hours. Upon completion of the reaction, the palladium/carbon catalyst was removed by filtration, followed by concentration under reduced pressure to remove the solvent. The colorless liquid product oxetan-3-ol (142.63 g) was obtained by distillation in 95.84% yield.
References
[1] Patent: CN103554064, 2016, B. Location in patent: Paragraph 0031; 0032; 0041; 0042
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Oxetan-3-ol(7748-36-9)Related Product Information
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- ethyl 2-(oxetan-3-ylidene)acetate
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- 3-Oxetanethiol
- 3-OXETANECARBOXYLIC ACID
- 2-aminomethyloxetane
- TOLUENE-4-SULFONIC ACID OXETAN-2-YLMETHYL ESTER
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