Methyl maslinate
Methyl maslinate Basic information
- Product Name:
- Methyl maslinate
- Synonyms:
-
- Methyl maslinate
- (2α,3β)-2,3-Dihydroxy-olean-12-en-28-oic acid methyl ester
- (2alpha,3beta)-2,3-Dihydroxy-olean-12-en-28-oic acid methyl ester
- Methyl 2α-hydroxyoleanolate
- Olean-12-en-28-oic acid, 2,3-dihydroxy-, methyl ester, (2α,3β)-
- CAS:
- 22425-82-7
- MF:
- C31H50O4
- MW:
- 486.73
- Product Categories:
-
- Pentacyclic Triterpenes
- Mol File:
- 22425-82-7.mol
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Methyl maslinate Usage And Synthesis
Uses
Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research[1].
in vivo
Methyl maslinate (MM) (20-60 mg/kg; i.p.) shows significant, dose-dependent vasodepressor effect and sinus bradycardia, lasting more than 60 minutes with a maximum at 20 minutes, and shows potent hymodynamic effect[1].
Methyl maslinate (40 mg/kg) shows antidysrhythmic activity on ischemia-reperfusion dysrhythmia[1].
| Animal Model: | Wistar male rats (300-320 g)[1] |
| Dosage: | 20-60 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Showed significant, dose-response vasodepressor effect and sinus bradicardia. Antagonized β-Adrenergic. Showed antidysrhythmic activity. |
References
[1] Somova LI, et al. Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine. 2004 Feb;11(2-3):121-9. DOI:10.1078/0944-7113-00329
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