Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). Chemical Properties

Boiling point:

383.99°C (rough estimate)

Density 

1.2650 (rough estimate)

refractive index 

1.5300 (estimate)

storage temp. 

-20°C

solubility 

DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 1 mg/ml

form 

A crystalline solid

pka

10.70±0.40(Predicted)

color 

Off-white to gray

EPA Substance Registry System

2-(1-Oxo-2-isoindolinyl)glutarimide (26581-81-7)

Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). Usage And Synthesis

Description

Phthalimidine, 2-(2,6-dioxopiperiden-3-yl) is a lenalidomide analog that can be useful in PROTAC research.

General Description

White crystalline powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). is an example of an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). are not available; however, Phthalimidine, 2-(2,6-dioxopiperiden-3-yl). is probably combustible.

Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).(26581-81-7)Related Product Information

• Isoindoline
• Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).
• Thalidomide
• 5'-HYDROXY THALIDOMIDE
• Lenalidomide
• 2-[2,6-DIOXO-3-(TRIFLUOROMETHYL)PIPERIDIN-3-YL]-1H-ISOINDOLE-1,3(2H)-DIONE
• (R)-(+)-THALIDOMIDE
• (-)-THALIDOMIDE