Basic information Safety Supplier Related

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol

Basic information Safety Supplier Related

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Basic information

Product Name:
[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
Synonyms:
  • [2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol
  • 4-Quinolinemethanol,2-(4-chlorophenyl)-a-2-piperidinyl-
  • Vacquinol-1
  • NSC 13316
  • NSC 13316;NSC13316;NSC-13316;VACQUINOL 1;VACQUINOL1
  • NSC13316
  • NSC-13316
  • CS-2185
CAS:
5428-80-8
MF:
C21H21ClN2O
MW:
352.86
Product Categories:
  • building block
Mol File:
5428-80-8.mol
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Chemical Properties

Melting point:
198-199.5 °C
Boiling point:
551.4±50.0 °C(Predicted)
Density 
1.244±0.06 g/cm3(Predicted)
pka
13.22±0.20(Predicted)
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[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanol Usage And Synthesis

Description

Vacquinols are a new class of quinine-derivatives that stimulate death in glioblastoma cells by massive macropinocytotic vacuolization, ATP depletion, and cytoplasmic membrane rupture. A key effector of vacquinols is MAPK kinase 4 (MKK4). Vacquinol-1 is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. It induces ATP depletion in glioblastoma cells (IC50 = 3.14 μM at 1 day) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. Vacquinol-1 is orally bioavailable with good brain penetrance and excellent pharmacokinetics. Oral administration of vacquinol-1 (20 mg/kg once daily for five days) substantially impairs the growth of engrafted glioblastoma cell tumors in mice and prolongs survival.

Uses

Vacquinol-1 is in the vacquinol class of quinine derivatives that stimulate death in glioblastoma cells through massive macropinocytotic vacuolization, ATP depletion and eventual cytoplasmic membrane rupture.

[2-(4-chlorophenyl)quinolin-4-yl]-(2-piperidyl)methanolSupplier

EnliPharma Technology Co., Ltd
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Amadis Chemical Company Limited
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571-89925085
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