SPERMINE NONOATE Chemical Properties

Melting point:

105-107°C

Boiling point:

405.6°C (rough estimate)

Density 

1.0879 (rough estimate)

refractive index 

1.7000 (estimate)

storage temp. 

-20°C

solubility 

methanol: ≥1mg/mL

form 

White solid

pka

5.47±0.69(Predicted)

color 

white

Stability:

Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use.

Safety Information

Safety Statements 

22-24/25

SPERMINE NONOATE Usage And Synthesis

Description

Spermine NONOate (136587-13-8) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner.? ? The half-life of Spermine NONOate in 0.1 M phosphate buffer at pH 7.4 is 39 min at 37 °C, or 230 min at room temperature.1? ? Dissociation is essentially instantaneous at a pH of 5.0.

Chemical Properties

Off-White Solid

Uses

A reagent which releases Nitric Oxide into aqueous solutions at controlled rates for in vitro studies.

General Description

Complex of nitric oxide (NO) with spermine. Convenient reagent for preparing aqueous solutions of NO. Half-life (t_?) of NO release = 230 min (PBS, pH 7.4, 22°C).

Biological Activity

A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC 50 = 6.2 μ M for relaxation of rabbit aorta, and t=39 min at 37℃, pH 7.4, aqueous solution).

Biochem/physiol Actions

Product does not compete with ATP.

References

1) Keefer et al. (1996), “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol., 268 281

SPERMINE NONOATE(136587-13-8)Related Product Information

• Sodium nitroprusside dihydrate
• NOC-18
• DPTA NONOATE
• NOC-7
• MAHMA NONOATE
• 4-(N-CYANOMETHYL-N-NITROSO)AMINOMORPHOLINE
• S-NITROSOGLUTATHIONE
• NOC-5
• BETA-GAL-NONOATE
• GEA 3162
• NOR-3
• Ethylenediamine
• NITRIC OXIDE
• Dipentene
• SPERMINE DIHYDRATE
• SPERMINE NONOATE
• PAPA NONOATE
• DEA NONOATE