2-Methyl-5-nitropyridine Chemical Properties

Melting point:

112 C

Boiling point:

237.1±20.0 °C(Predicted)

Density 

1.246±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

1.92±0.10(Predicted)

form 

Solid

color 

Light yellow to Brown

Water Solubility 

Slightly soluble in water.

InChI

InChI=1S/C6H6N2O2/c1-5-2-3-6(4-7-5)8(9)10/h2-4H,1H3

InChIKey

USZINSZJSVMICC-UHFFFAOYSA-N

SMILES

C1(C)=NC=C([N+]([O-])=O)C=C1

CAS DataBase Reference

21203-68-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

HS Code 

2933399990

2-Methyl-5-nitropyridine Usage And Synthesis

Uses

2-Methyl-5-nitropyridine is used as pharmaceutical intermediate.

Synthesis

2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester could be used as a starting material to synthesize 2-methyl-5-nitropyridine. The specific operations are as follows: To 2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester (12.0 g, 42.5 mmol) was added cold aq. 20% sulfuric acid (120 mL) and the mixture was heated to 100 ℃ for 2h. The cooled reaction was added to a cold dilute sodium hydroxide solution and the pH adjusted to 10. The organics were extracted with dichloromethane (x 4), and then the combined organic phases were dried over sodium sulfate. The filtrate was concentrated to afford 2-methyl-5-nitropyridine (5.0 g, 83 %) as a brown solid.

2-Methyl-5-nitropyridine(21203-68-9)Related Product Information

• 2-Methyl-3-nitropyridine
• 2-Bromo-5-nitropyridine
• Thiophanate-methyl
• 5-Bromo-2-methylpyridine
• 2-Methyl-4-nitropyridine
• Bensulfuron methyl
• 2-Picoline
• Methylparaben
• 2-Methoxy-5-nitropyridine
• Methyl propyl carbonate
• Azamethiphos
• Methyl acetate
• Kresoxim-methyl
• 5-Ethyl-2-methylpyridine
• 4-Methylpyridine
• 2,4,6-Collidine
• METSULFURON METHYL
• Methyl