CKS 17
CKS 17 Basic information
- Product Name:
- CKS 17
- Synonyms:
-
- Aids002113
- Aids-002113
- Leu-Gln-Asn-Arg-arg-Gly-Leu-Asp-Leu-leu-Phe-Leu-Lys-Glu-Gly-gly-Leu linked to bsa
- L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-.alpha.-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-.alpha.-glutamylglycylglycyl-
- Lqnrrgldllflkeggl-bsa
- CKS-17 H-Leu-Gln-Asn-Arg-Arg-Gly-Leu-Asp-Leu-Leu-Phe-Leu-Lys-Glu-Gly-Gly-Leu-OH
- L-Leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-α-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-α-glutamylglycylglycyl-L-leucine
- L-Leucine, L-leucyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginylglycyl-L-leucyl-L-α-aspartyl-L-leucyl-L-leucyl-L-phenylalanyl-L-leucyl-L-lysyl-L-α-glutamylglycylglycyl-
- CAS:
- 99273-04-8
- MF:
- C87H148N26O24
- MW:
- 1942.28
- Mol File:
- 99273-04-8.mol
CKS 17 Chemical Properties
- Density
- 1.41±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 3.40±0.10(Predicted)
CKS 17 Usage And Synthesis
Uses
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions[1][2][3].
in vivo
CKS-17 (10 μM; i.d.; B6AF1 mice and C57BL/6J mice) inhibits delayed-type hypersensitivity (DTH) reactions to sheep erythrocytes in the feet of mice[2].
| Animal Model: | B6AF1 mice and C57BL/6J mice with DTH models[2] |
| Dosage: | 10 μM |
| Administration: | Intradermal injection, into the right hind footpad |
| Result: | Had a transient depressive effect on DTH reaction. |
References
[1] Haraguchi S, et, al. Induction of intracellular cAMP by a synthetic retroviral envelope peptide: a possible mechanism of immunopathogenesis in retroviral infections. Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5568-71. DOI:10.1073/pnas.92.12.5568
[2] Nelson M, et, al. Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. Cancer Immunol Immunother. 1989;30(2):113-8. DOI:10.1007/BF01665962
[3] Nelson M, et, al. Inhibition of interleukin-2 production by tumor cell products and by CKS-17, a synthetic retroviral envelope peptide. Cancer Immunol Immunother. 1990;30(6):331-41. DOI:10.1007/BF01786882
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