abciximab Chemical Properties

storage temp. 

Store at -80°C

form 

Liquid

color 

Colorless to light yellow

Safety Information

Hazardous Substances Data

143653-53-6(Hazardous Substances Data)

abciximab Usage And Synthesis

Uses

Monoclonal antibody (antithrombotic).

brand name

ReoPro (Lilly).

Clinical Use

Antiplatelet agent:
Prevention of ischaemic cardiac complications in patients undergoing percutaneous coronary intervention
Short-term prevention of myocardial infarction in patients with unstable angina not responding to treatment or awaiting percutaneous coronary intervention.

Enzyme inhibitor

This antithrombotic (MW = 47455 g/mol; CAS 143653-53-6; also known as Reopro?) consists of an immunoglobulin G1 Fab fragment from a chimeric human-murine monoclonal antibody directed against the human platelet glycoprotein IIb/IIIa receptor. Abciximab also facilitates the dispersal of newly formed platelet aggregates in vitro, by partially displacing fibrinogen from activated GPIIb/IIIareceptors. In vivo, abciximab may destabilize coronary thrombi by preventing aggregate formation and dispersing mural thrombi. Target(s): coagulation factor Xa, in presence of heparin; glycoprotein IIb/IIIa receptor.

Drug interactions

Potentially hazardous interactions with other drugs
Heparin, anticoagulants, antiplatelets and thrombolytics: increased risk of bleeding.

Metabolism

Following IV administration, abciximab rapidly binds to the platelet GPIIb/IIIa receptors, and remains in the circulation for 15 days or more in a platelet-bound state. Metabolism is via proteolytic cleavage

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