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sphondin

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sphondin Basic information

Product Name:
sphondin
Synonyms:
  • sphondin
  • 6-Methoxy-2H-furo[2,3-h][1]benzopyran-2-one
  • 6-Methoxy-2H-furo[2,3-h]-1-benzopyran-2-one
  • 2H-Furo(2,3-h)-1-benzopyran-2-one, 6-Methoxy-
  • Sfondin
  • 6-Methoxy-2H-furo[2,3-h]chromen-2-one
  • 6-Methoxyangelicin
CAS:
483-66-9
MF:
C12H8O4
MW:
216.19
Mol File:
483-66-9.mol
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sphondin Chemical Properties

Melting point:
189-191 °C
Boiling point:
413.0±45.0 °C(Predicted)
Density 
1.368±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Solid
color 
Off-white to light yellow
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Safety Information

Hazardous Substances Data
483-66-9(Hazardous Substances Data)
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sphondin Usage And Synthesis

Chemical Properties

Off-white needle-like crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Oxtail Duhuo.

Uses

Sphondin has an Analgesic, anti-inflammatory, anti-allergic, smooth muscle spasmolytic effect.

Definition

ChEBI: Sphondin is a furanocoumarin.

Biological Activity

Sphondin, isolated from Heracleum laciniatum, has inhibitory effects on IL-1β-induced increases in COX-2 protein and PGE2 release levels in A549 cells.

in vitro

Pretreatment of A549 cells with Sphondin (10-50 μM) concentration-dependently attenuates IL-1β-induced COX-2 protein expression and PGE 2 release.

target

COX-2

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