anhydrotetrodotoxin
anhydrotetrodotoxin Basic information
- Product Name:
- anhydrotetrodotoxin
- Synonyms:
-
- anhydrotetrodotoxin
- (8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin
- 4,9-Anhydrotetrodotoxin
- 4,9-Dideoxy-4β,9β-epoxytetrodotoxin
- (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
- 6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-
- 9-anhydro-TTX
- 4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin
- CAS:
- 13072-89-4
- MF:
- C11H15N3O7
- MW:
- 301.25
- Mol File:
- 13072-89-4.mol
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anhydrotetrodotoxin Chemical Properties
- storage temp.
- -20°
- solubility
- Soluble in Ethanol (up to 10 mg/ml).
- form
- A solid or film
- color
- Colorless
- Water Solubility
- Soluble to 1 mg/ml in water
- Stability:
- Stable for 2 years from date of purchase as supplied. Protect from exposure to light or moisture. Solutions are not stable. Solutions must be prepared fresh and used within 1 working day.
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anhydrotetrodotoxin Usage And Synthesis
Description
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 μM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.
storage
Store at -20°C
References
1) Rosker?et al. (2007),?The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol.,?293?C783. 2) Denomme?et al.?(2020),??The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6;?Neurosci. Lett.?724?134853
anhydrotetrodotoxinSupplier
Shanghai Hongye Biotechnology Co. Ltd
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- 400-9205774
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TargetMol Chemicals Inc.
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BOC Sciences
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- info@bocsci.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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- 18818260767
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Energy Chemical
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- 021-58432009 400-005-6266
- marketing@energy-chemical.com
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- anhydrotetrodotoxin